LSC Research Groups

Research Core Facilities

MU Office of Research

LSC Grants/Fiscal Team

Last update: 09/20/07	Text size: A A A

Research Cores

Cell and Immunobiology Core (CIC)

The CIC provides custom monoclonal antibodies, flow cytometric analysis and tissue culture reagents. The Core is hosted by the Dept. of Molecular Microbiology and Immunology.

DNA Core

The DNA Core provides DNA sequencing, genotyping, SNP detection and analysis and microarray services; maintains a freezer inventory program for molecular biology enzymes and reagents; and provides support for computer analysis of nucleic acid and protein sequence data. Robotic instrumentation is available for high throughput plasmid isolation, colony picking and genomic library management. The Affymetrix GeneChip® System has also been added to the DNA Core. The GeneChip® Instrument System is a fully integrated platform for Affymetrix application-specific oligonucleotide arrays, the GeneChip® probe arrays. The integrated system includes the GeneArrayT scanner, the GeneChip® Fluidics Station (model 400), the GeneChip® Hybridization Oven 640, and a powerful computer workstation loaded with the Affymetrix Microarray Suite. The Core is hosted by the Dept. of Molecular Microbiology and Immunology.

Electron Microscopy Core (EMC)

The EMC is a campus-wide resource center for research that requires scanning or transmission electron microscopy, providing investigators in both life sciences and material sciences with consultation, training and services. The facility was established with resources from the College of Veterinary Medicine, the School of Medicine, the College of Agriculture, Food and Natural Resources, the Department of Geological Sciences and the Molecular Biology Program. The Core is hosted by the Department of Veterinary Pathobiology.

Molecular Cytology Core (MCC)

The MCC is a resource for all types of light microscopy, immunocytochemistry, in situ hybridization techniques and general scientific image analysis and processing. Instrumentation available for client use includes two confocal microscopes, micro-injection system, epi-fluorescence stereoscope, conventional wide-field microscopes, paraffin microtome, cryostat, and ultramicrotome. Complete details about our services and instrumentation can be found at http://www.biotech.missouri.edu/mcc/ . The MCC is hosted by the Life Sciences Center.

Nuclear Magnetic Resonance (NMR) Core

The NMR Facility is a campus-wide resource hosted by the Department of Chemistry. The NMR Facility was the first core research facility to be established at MU and continues to serve researchers from many disciplines. Instrumentation includes a Varian Inova 600 MHz spectrometer, a Bruker DRX 500 MHz spectrometer, an ARX 250MHz spectrometer and a DRX 300 MHz (widebore) spectrometer with solid state capability. A new Bruker Advance Ultra Stabilized 800 MHz spectrometer was added in early 2008 and is housed in the Schweitzer Hall Addition. All spectrometers have multinuclear capabilities. The NMR Facility and staff are available for research support to investigators who want to use NMR for structural elucidation and for the study of chemical and biological reactions. Assistance in the design of experiments and spectral analysis is available upon request.

Proteomics Center

The Proteomics Center was developed through the collaborative efforts of the Office of Research, the Molecular Biology Program, the College of Arts and Sciences, and the College of Agriculture, Food and Natural Resources. The Proteomics Center offers state-of-the-art technologies in protein and peptide separation and analysis to all MU researchers. The Center is located on the second floor of the Bond Life Sciences Center. Assistance in the design of experiments and spectral analysis is available. For additional information, please consult the Center’s website.

Structural Biology Core (SBC)

The Structural Biology Core Facility (SBC) offers assistance in unraveling the three-dimensional structure of biological molecules by providing technical expertise in protein purification and crystallization and instrumentation for NMR Spectroscopy and X-ray diffraction analysis. Beamline services are also available through the SBC. The SBC has been established under the umbrella of the Molecular Biology Program. Supported by Mission Enhancement, the Depts. of Biochemistry and Chemistry, and the Molecular Biology Program, the SBC provides centralized access to structural biology resources, facilitates collaborations between faculty with expertise in structural biology and other MU life scientists, and strengthens proposals for extramural funding.

Transgenic Animal Core (TAC)

The TAC is now open for business under the direction of Dr. Elizabeth Critser and has completed several successful projects to date. For complete information on services, visit the TAC website and or contact Dr. Critser at (573) 882-6518. The Transgenic Animal Core Facility is supported by the Molecular Biology Program, the College of Veterinary Medicine and the Comparative Medicine Center at the University of Missouri-Columbia.